On the use of random graphs in analysing resource utilization in urban systems

Urban resource models increasingly rely on implicit network formulations. Resource consumption behaviours documented in the existing empirical studies are ultimately by-products of the network abstractions underlying these models. Here, we present an analytical formulation and examination of a generic demand-driven network model that accounts for the effectiveness of resource utilization and its implications for policy levers in addressing resource management in cities. We establish simple limiting boundaries to systems' resource effectiveness. These limits are found not to be a function of system size and to be simply determined by the system's average ability to maintain resource quality through its transformation processes. We also show that resource utilization in itself does not enjoy considerable size efficiencies with larger and more diverse systems only offering increased chances of finding matching demand and supply between existing sectors in the system

Compact graphene mode-locked wavelength-tunable erbium-doped fiber lasers: from all anomalous dispersion towards all normal dispersion

Soliton operation and soliton wavelength tuning of erbium-doped fiber lasers mode locked with atomic layer graphene was experimentally investigated under various cavity dispersion conditions. It was shown that not only wide range soliton wavelength tuning but also soltion pulse width variation could be obtained in the fiber lasers. Our results show that the graphene mode locked erbium-doped fiber lasers provide a compact, user friendly and low cost wavelength tunable ultrahsort pulse source

Characterizing the entanglement of bipartite quantum systems

We derive a separability criterion for bipartite quantum systems which generalizes the already known criteria. It is based on observables having generic commutation relations. We then discuss in detail the relation among these criteria.Comment: 5 pages, 2 figures. Revised versio

Management of oromandibular dystonia with botulinum A toxin: a series of cases.

Oromandibular dystonia is a disorder of movement that is often misdiagnosed. We present our experience of six patients treated with botulinum A toxin, for whom we recorded the symptoms, the group of muscles targeted, and the quantity of botulinum toxin used. We used the Glasgow Benefit Inventory (GBI) questionnaire to record and analyse outcomes after treatment. Five of the six patients had a good outcome as recorded by the GBI, the mean (SD) score of which was +40 (28), which reflected that the patients were well satisfied. The overall improvement in the categories of general health, social health, and physical health were 82%, 37%, and 31%, respectively. Botulinum type A toxin is an effective treatment of oromandibular dystonia. It is important for clinicians to recognise the condition, as treatment is well-tolerated and can improve quality of life

An ecological-thermodynamic approach to urban metabolism : measuring resource utilization with open system network effectiveness analysis

Cities have evolved as centers of economic growth and often described as open systems where the intake of resources is heavily dependent on flows imported from the external environment. The question is, how much of the resource available in cities is effectively utilized? In response, this paper develops an ecological-thermodynamic approach to assess the ability of a system to make full use of the resources available and reduce the demand for new resources. In this work, open system network effectiveness analysis is introduced as a novel assessment method to investigate the cities’ producer and consumer behaviors by studying the resource flow connections and the interactions between the socio-economic sectors. Investigation on the urban flows network evaluates the ability of the system to utilize the resource imported through the effectiveness of utilization indicator and the ability to convert the resource imported to useful products through the effectiveness of conversion indicator. The effectiveness indicators, utilization and conversion, represent the consumption and production characteristics of the system respectively. This is tested through a case study conducted for Singapore city over the time period 2005-2014. The effectiveness results show that the city, on average, has utilized 45% of the maximum extractable usefulness from the resources imported throughout the years, with the lowest effectiveness, 39%, and the highest effectiveness, 50%, in the years 2007 and 2014 respectively. The trajectory of effectiveness results throughout the years suggests a trade-off relationship between the producers and consumers to balance the production and consumption of resources in the city

Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?

Metastatic melanoma remains a fatal disease to many worldwide, even after the breakthrough introduction of targeted therapies such as BRAF inhibitors and immune checkpoint blockade therapies such as CTLA-4 and PD-1 inhibitors. With advances in our understanding of this disease, as well as the increasing data gathered from patient studies, the significance of the host immune response to cancer progression and response to treatment is becoming clear. More specifically, the presence of intratumoral CD8⁺ cytotoxic T-cells correlates with better prognosis whereas the accumulation of monocytes/macrophages and neutrophils in the tumour is often associated with worse prognosis. Access and infiltration of circulating leukocytes into the tumour is governed by adhesion molecules and chemokines expressed by the endothelial cells of the vasculature. This review focuses on the adhesion molecules and chemokines which control the homing of CD8⁺ cytotoxic T-cells, monocytes and neutrophils to peripheral tissues, including tumours. We discuss the role of these leukocyte subsets in regulating melanoma growth, and detail the mechanisms used by tumours to selectively recruit or exclude these leukocytes for their own advantage. In doing so, we bring to light an underappreciated component of tumour biology which should be considered in combination with current treatments to selectively alter the leukocyte composition of tumours and ultimately enhance treatment outcome.Lih Yin Tan, Carmela Martini, Zvi G Fridlender, Claudine S Bonder, Michael P Brown and Lisa M Eber